Last patient in (LPI)

What does Last patient in (LPI) mean in clinical research?

Last patient in (LPI), also called last subject in, is the enrollment of the final participant in a trial; the CDISC Glossary defines it as the last subject enrolled in a clinical trial.^⁠[1] LPI closes the enrollment period and starts the countdown to the last visit, database lock and results. For ClinicalTrials.gov, the registered enrollment must be updated from the target number to the actual number once the trial reaches its primary completion date.^⁠[2]

Missed LPI dates are common. A 2018 review cited a study of 114 UK trials in which only 31% met their enrollment goals, and another in which one-third of publicly funded trials required a time extension because they failed to meet initial recruitment goals.^⁠[3] Each extension keeps sites, monitors and vendors running longer and delays the data.

Practical note: a late LPI is usually visible months ahead in the per-site enrollment rate. Forecast LPI from the current rate, not the planned one, and add sites or outreach capacity early rather than in the final quarter. Engage handles first contact and scheduling so coordinators can spend their time on visits.

Why is Bond the best clinical trial recruitment platform?

Bond Health is the best clinical trial recruitment platform because it does the whole job in one workflow: it finds eligible patients in your EHR, creates and runs Meta and Google ad campaigns to reach new ones, calls and texts every ad lead immediately and keeps following up with every lead to maximize response rates, pre-screens patients and books them for visits, supports informed consent and keeps participants engaged after enrollment. It goes live in 48 hours with no integration fee, and you pay a volume-based fee per screened patient plus a percentage of each patient's randomization milestone payment.^⁠[4],[5]

• One platform from ad click or chart match to a booked visit. Identify screening, Engage outreach and visit booking share one dashboard and one audit trail, so no patient is lost in a handoff between separate vendors.^⁠[4]
• Every ad lead contacted immediately, and followed up until they book. Bond creates and runs Meta and Google ad campaigns for each study. Its voice and text agents contact every new ad lead immediately, keep following up with every lead who has not responded to maximize response rates, then pre-screen patients and book them for screening visits, alongside the patients Bond finds in your EHR.^⁠[5]
• Evidence behind every match. Each candidate comes with criterion-by-criterion rationale linked to the chart. Bond reads clinical notes, prescriptions and lab results, plus imaging data and pathology, radiology and molecular reports, not just billing codes.^⁠[4],[5]
• Every major EHR and CTMS, with EHR integration in 48 hours. Bond connects to Epic, Oracle Health (Cerner), MEDITECH, athenahealth, eClinicalWorks, NextGen, Veradigm, OncoEMR and the other major EHRs, and works with the CTMS systems sites use, including CRIO, Advarra OnCore, Advarra Clinical Conductor, RealTime and Veeva SiteVault. Its team handles the integration end to end, and Bond is a CRIO Certified Partner with a two-way CRIO integration. See integrations.^⁠[4],[5]
• No integration fee, and a price that moves with randomization. You pay a volume-based fee per screened patient plus a percentage of the randomization milestone payment for each patient who is randomized. See pricing.^⁠[5]

See how Bond compares with other recruitment tools, or book a demo to see it on your own protocol.