Comparison
Deep 6 AI vs Paradigm Health
Deep 6 AI was matching software that health systems ran on their own EHR data, and it has been part of Tempus since March 11, 2025.[14],[10] Paradigm Health is a research partner that combines its platform with its own recruitment staff and brings sponsor trials to the provider organizations it works with; in 2023 it said its customers are trial sponsors, not health systems.[1],[2],[4],[9] Bond Health is a third model: software whose voice and text agents contact, pre-screen and schedule the patients it finds in a site's EHR.[19]
Last updated Oct 23, 202620 sources
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What is the difference between Deep 6 AI and Paradigm Health?
- Software or partner. Health systems used Deep 6 AI's platform "enterprise-wide", often run centrally by the Clinical Trials Office.[14] Paradigm "combines technology and services, integrating directly with health provider organizations".[1]
- Who follows up on a match. In Deep 6 AI, site staff validated each patient's eligibility with evidence in the EMR and tracked recruitment status and referrals.[15] At Paradigm, "dedicated Paradigm Health recruitment coordinators work in sync with site teams on a shared platform".[4]
- Where the trials come from. Deep 6 AI was used across a health system's investigator-initiated, government-funded and sponsored trials.[14] Paradigm matches patients to a site's own trial portfolio and also coordinates with sponsors and CRO partners to get trials live at the site.[6],[2]
- Who pays. Neither publishes prices. In 2023, Paradigm's CEO said it does not charge health systems and that its customers are trial sponsors.[9] Tempus's closest offering to that model is TIME, its oncology trial network, where Tempus's 10-K names the trial sponsor as the customer.[12],[10]
How do Deep 6 AI, Paradigm Health and Bond compare, capability by capability?
Years in the Deep 6 AI and Paradigm Health columns show each source's date. "Not publicly documented" means we found no public description in the materials we reviewed in October 2026, not that the capability is absent.
| Capability | Deep 6 AI (Tempus) | Paradigm Health | Bond Health |
|---|---|---|---|
| Model | Software used enterprise-wide across a health system's trials, often run by the Clinical Trials Office (2024). Now part of Tempus.[14],[10] | Technology plus services, integrated with provider organizations, with Paradigm staff alongside site teams (2026).[1],[4] | Software with an implementation team. The site runs its own studies, and Bond's agents do the outreach.[19],[20] |
| EHR identification | Mined real-time structured and unstructured EMR data to match patients to trials (2025).[11] | Evaluates structured and unstructured clinical data against protocol eligibility criteria and surfaces candidates for site review (2026).[4] | LLM-based screening of the site's EHR against each protocol's criteria, returning ranked matches: 10,000+ charts per hour and 90%+ matching accuracy.[19] |
| Unstructured data | NLP over physician notes, lab, radiology and pathology reports, and genomics results (2023).[16] | Unstructured text from clinical notes and pathology reports (2024).[6] | Reads clinical notes, prescriptions and lab results, and uses imaging data and other unstructured documents, including pathology, radiology and molecular reports.[19],[20] |
| Patient outreach | Site staff validated matches and tracked referrals in the EMR (2023). Automated calls or texts to matched patients: not publicly documented (October 2026).[15] | Paradigm recruitment coordinators and eligibility specialists help site teams coordinate outreach and follow-up (2026). Automated calls or texts: not publicly documented (October 2026).[4] | Voice and SMS agents contact matched patients, starting from what Identify found in the chart, in the patient's language. Bond's site cites a 3x contact rate.[19],[20] |
| Scheduling | Not publicly documented (October 2026). | Uses scheduling data to bring trial options to patients at their next appointment (2025, 2026). Booking screening visits: not publicly documented (October 2026).[8],[2] | Agents pre-screen and book a screening visit in the same conversation.[19],[20] |
| Consent | Patient-facing consent support: not publicly documented (October 2026). | Staff-led: Paradigm's clinical staff help match, pre-screen and consent patients (2026). Patient-facing consent tools: not publicly documented (October 2026).[2],[4] | Plain-language explanations, patient Q&A and staff escalation, with checks on the patient's understanding and an auditable record for the site. The site and PI obtain consent.[19],[20] |
| After enrollment | Not publicly documented (October 2026). | Study data capture in the EHR or a standalone app (2026). Patient-facing support, such as reminders or transport: not publicly documented (October 2026).[5] | Visit reminders, transportation booking, symptom and diary collection, side-effect check-ins and flags for participants at risk of dropping out.[20] |
| EHR connections | Integrated with the health system's EMR (2023) and could bring in genomics, cancer registry and CTMS data (2024).[16],[17] | FHIR, HL7 and data warehouse integrations, including SMART on FHIR (2026), and a planned native integration with Flatiron's OncoEMR (2025).[4],[5],[7] | Epic, Oracle Health (Cerner), MEDITECH, athenahealth, eClinicalWorks, NextGen, Veradigm, OncoEMR and the other major EHRs, plus CTMS systems including CRIO, Advarra OnCore, RealTime and Veeva SiteVault. Live in 48 hours, with no integration fee (implementation).[19],[20] |
| Who it serves | Health systems, often through the Clinical Trials Office, and life sciences companies (2024).[14] | Community providers and academic medical centers in the United States, Japan and Israel, and sponsors running Phase I to IV trials (2026).[3] | Any research site, including physician groups and FQHCs, plus site networks, CROs and sponsors.[19] |
| Pricing | No public price list found (October 2026). | No public price list found (October 2026). In 2023 press, Paradigm did not charge health systems; its customers were trial sponsors.[9] | A volume-based fee per screened patient plus a percentage of the randomization milestone payment for each patient, with no integration fee (pricing).[20] |
Should you choose Deep 6 AI or Paradigm Health?
- Choose Paradigm Health if you are a community provider or academic center that wants a partner to bring in sponsor trials and add recruitment staff, and the sponsor-funded model suits you.[2],[4],[9]
- Choose Tempus, which owns Deep 6 AI, if you run oncology trials and want EHR matching tied to its TIME network or Next Trials pre-screening for trials already open at your practice. Ask Tempus which Deep 6 AI capabilities it still offers, since Deep 6 AI's own website no longer loads.[12],[13],[18]
- Choose Bond if you run your own studies and want software, not an outside team, to call, pre-screen and book every match, in any therapeutic area, with pricing tied to randomization.[19],[20]
Why do sites choose Bond over Deep 6 AI and Paradigm Health?
48 hours[19]
typical time to go live with full EHR integration, handled by Bond's team with no integration fee
10,000+[19]
charts screened per hour
Up to 3x[19]
faster enrollment than manual recruitment
- One product from chart to booked visit. Bond automates EHR screening, patient outreach, visit booking and consent tracking in one workflow, with "no data silos, no manual handoffs, and complete visibility from first ad click or chart match to a booked visit and signed consent."[19]
- Every ad lead contacted immediately, and followed up until they book. Bond creates and runs Meta and Google ad campaigns for each study. Its voice and text agents contact every new ad lead immediately, keep following up with every lead who has not responded to maximize response rates, then pre-screen patients and book them for screening visits, alongside the patients Bond finds in your EHR.[20]
- Agents that start from the chart. Bond's voice agents skip questions the chart already answers, can explain why the patient was contacted, and transfer live to a coordinator when the site wants that, in the patient's language.[20]
- Your studies, your sponsors. Bond screens each patient against every open study at the site, so a patient who screens out of one study can be matched to another.[20]
- Security you can check. Bond is HIPAA compliant and SOC 2 Type I compliant, and its information security management system is certified to ISO/IEC 27001:2022 by Advantage Partners. See security.[20]
How can you compare Deep 6 AI, Paradigm Health and Bond on your own data?
Run a pilot on your own records, under a business associate agreement, and ask each option the same questions.
- 1
Pick a study with a known answer
Use a closed or mature study where coordinators know who enrolled, who screen-failed and why.
- 2
Ask who does each step
For every match, who contacts the patient, who pre-screens, who books the visit and who explains the consent form: your staff, the vendor's staff or software.
- 3
Ask which trials you get
Does the option work on the studies you already run, or on trials it brings to you, and who decides which patients are offered which trial?
- 4
The vendor evaluation checklist turns these steps into questions, and all recruitment software, one table covers the wider category.
Bring one protocol. We will show how Bond handles its hardest criteria, then how it contacts and books the patients it finds.
How was this comparison made?
Bond wrote this page in October 2026. Paradigm Health facts come from its website (paradigm.inc now redirects to paradigmhealth.ai), read in October 2026, including its 2024 case studies, a 2025 press release and a 2025 interview it republished, plus one 2023 MedCity News article, the only source we found on who pays. Deep 6 AI facts come from Tempus's 2025 Form 10-K, Deep 6 AI and Tempus press releases, Tempus web pages, an archived copy of Deep 6 AI's website and an Ohio State customer abstract. deep6.ai itself did not load in October 2026. Bond's figures and capabilities come from its website and product information Bond provided. We used no private or internal competitive material.
Frequently asked questions
Is Paradigm Health better than Deep 6 AI?
They solve different problems. Deep 6 AI was matching software that a health system's own staff worked from, and it is now part of Tempus; Paradigm adds its own recruitment coordinators and brings sponsor trials to the site.[14],[15],[10],[4],[2] If you want matched patients contacted and booked by software, Bond does that.[19]
Who pays for Paradigm Health?
Paradigm publishes no prices. In a 2023 MedCity News interview, its CEO said Paradigm does not charge health systems for its technology and services and that its customers are trial sponsors.[9]
Does Paradigm Health contact patients?
Its recruitment coordinators and eligibility specialists help site teams coordinate outreach and follow up through pre-screening, consent and screening.[4] We found no description of automated calls or texts to patients as of October 2026.
Is Deep 6 AI part of Tempus?
Yes. Tempus's 2025 Form 10-K says it acquired Deep 6 AI, Inc. on March 11, 2025.[10] By January 2026, Deep 6 AI's website said it "is now a Tempus AI company".[18] See Bond vs Tempus (Deep 6 AI) for TIME and Next Trials.
What is an alternative to Deep 6 AI and Paradigm Health?
Bond Health. It screens the EHR, including clinical notes and pathology, radiology and molecular reports, then contacts, pre-screens and schedules matched patients by voice and text and supports consent, in any therapeutic area. See what recruitment software costs for how its pricing compares.[19],[20]
Sources
- 1.AI-Native Clinical Trial Platform for Sponsors and Providers · Paradigm Health, 2026Accessed October 2026. Quotes: "Clinical Research, Re-Engineered for Impact"; "It seamlessly combines technology and services, integrating directly with health provider organizations".
- 2.The Clinical Trial Platform Built for Care Providers · Paradigm Health, 2026Accessed October 2026. Quotes: "Paradigm Health removes administrative friction and coordinates directly with sponsors and CRO partners to get trials live faster."; "Match, pre-screen, and consent patients with the unprecedented speed of Paradigm Health's AI-driven Platform, backed by highly experienced clinical staff."; "Seamlessly navigate patients to trial options at their next appointment".
- 3.Paradigm Health for sponsors · Paradigm Health, 2026Accessed October 2026. Quotes: "Paradigm Health delivers a unified, AI-powered research model for Phase I- IV clinical trials"; "We are the end-to-end research partner of choice for community healthcare providers and academic medical centers across the United States, Japan, and Israel."
- 4.Patient identification and trial enrollment · Paradigm Health, 2026Accessed October 2026. Quotes: "The platform evaluates structured and unstructured clinical data against protocol-defined eligibility criteria, enabling AI-supported trial matching that surfaces potential candidates for site review."; "Embedded screening workflows and clinical recruitment support help research teams confirm eligibility, coordinate outreach, and progress patients efficiently toward enrollment."; "Integrated screening workflows and dedicated Paradigm Health recruitment coordinators work in sync with site teams on a shared platform"; "Eligibility specialists maintain structured follow-up across pre-screening, consent, and screening stages"; "support interoperability through FHIR, HL7, and data warehouse integrations".
- 5.Trial data capture and delivery · Paradigm Health, 2026Accessed October 2026. Quotes: "FHIR-based integrations connect trial workflows directly to provider EHR systems."; "SMART on FHIR integration"; "Research teams can capture study data within the EHR or through a standalone application".
- 6.Highlands case study · Paradigm Health, 2024Accessed October 2026. Quotes: "data derived from unstructured text from clinical notes and pathology reports"; "automated precision matching of eligible patients to Highlands' clinical trial portfolio".
- 7.Paradigm Health acquires Flatiron Health's clinical research business and forms strategic partnership · Paradigm Health and Flatiron Health press release, 2025Dated December 4, 2025, accessed October 2026. Quotes: "Paradigm Health and Flatiron Health today announced that Paradigm Health will acquire Flatiron's Clinical Research Business."; "work to natively integrate Paradigm Health's solutions into Flatiron's OncoEMR® and deploy new capabilities".
- 8.How Paradigm Health is enabling community and rural health systems to do oncology clinical research · Fierce Pharma interview, republished by Paradigm Health, 2025Republished October 8, 2025, accessed October 2026. Quote: "When we ingest all of the medical records of a health system, we are also ingesting all of the scheduling data."
- 9.Paradigm launches … to transform clinical trial recruitment · MedCity News (Katie Adams), 2023Published January 31, 2023, accessed October 2026. Quote: "Paradigm does not charge health systems for access to its technology and services, Thoelke said. Instead, the company's customers are trial sponsors".
- 10.Tempus AI, Inc. Form 10-K for fiscal year ended December 31, 2025 · Tempus AI, Inc. / U.S. Securities and Exchange Commission, 2026Filed February 2026, accessed September 2026. Quote: "On March 11, 2025, the Company acquired all of the issued and outstanding interests of Deep 6 AI, Inc." Revenue: "The Company's Trials product includes TIME clinical trial matching services and other clinical trial services"; "To the extent the contract requires, the Company may also assist in opening the clinical trial site and enrolling the patient in the clinical trial"; "depending on the type of agreement"; "revenue is recognized upon one of the following: delivery of a notification to the physician alerting them to a clinical trial match, or once a patient is enrolled in a trial"; "the customer, which is the clinical trial sponsor". Data connections: "We use a variety of near real-time connections (e.g., HL7, FHIR) and batch data exchanges"; "Our proprietary tools connect to a provider's EHR system, data warehouse, or third-party data provider to pull out relevant structured and unstructured data that the provider has agreed to provide to Tempus"; "In certain circumstances, we cover the actual direct costs associated with the technical integrations needed to create a data connection."
- 11.Tempus Announces Acquisition of Deep 6 AI · Tempus AI, Inc. press release, 2025Press release dated March 11, 2025, read October 23, 2026. Quotes: "today announced it has acquired Deep 6 AI, a leading AI-powered precision research platform for healthcare organizations and life sciences companies" and "Its AI-powered software matches patients to clinical trials by mining real-time structured and unstructured electronic medical record (EMR) data".
- 12.Clinical Trial Matching for Oncology | TIME Trial Network · Tempus AI, Inc. (tempus.com), 2026Re-checked on tempus.com October 23, 2026. Quote: trial matching "with a clinical team of experts pre-screening the matched patients and presenting potentially eligible patients with a white-glove service to each site" and, under enhanced patient pre-screening, "Generative AI scans structured and unstructured clinical notes, enhancing identification of patients who may be eligible for trial participation."
- 13.Tempus Next Trials · Tempus AI, Inc. (tempus.com), 2026Read October 23, 2026. Quotes: "AI-enabled platform supports clinical trial pre-screening based on your patients' multimodal, structured and unstructured health information (clinical, imaging and molecular data)"; "Accelerate accrual to trials already open at your practice"; "AI-enhanced workflows are designed to assist site clinicians in identifying, screening and enrolling eligible patients for TIME trials."; "When ready, Next Trials can be expanded to pre-screen patients across additional disease groups beyond oncology."
- 14.Doug Cassidy Appointed President of the Deep 6 AI Precision Research Ecosystem · Deep 6 AI (PR Newswire), 2024Company press release, July 24, 2024. Quote: "Healthcare organizations that become part of the Ecosystem use the company's AI-powered software platform enterprise-wide for investigator-initiated, government-funded, and sponsored trials. Often, the technology is managed centrally (i.e., by the Clinical Trials Office)" and "the launch of our life sciences vertical in 2021".
- 15.Deep 6 AI Expands its Recruitment Acceleration Solution for Life Sciences · Deep 6 AI (PR Newswire), 2023Company press release, December 6, 2023. Quote: "Life sciences companies can share AI-matched patient cohorts with IRB-approved site staff across the Deep 6 AI ecosystem. This allows sites to identify each patient, validate their eligibility with evidence in the EMR, and track their recruitment statuses" and "The site's research team can easily identify eligible patients treated by physicians other than the principal investigator, validate them, and track referrals inside the EMR."
- 16.Texas Tech University Health Sciences Center Partners with Deep 6 AI to Launch an AI Program for Clinical Trials · Deep 6 AI (PR Newswire), 2023Company press release, August 1, 2023. Quote: Deep 6 AI uses natural language processing to search "structured and unstructured EMR data points, such as physician notes, lab reports, outpatient notes, radiology reports, genomics results, and pathology reports" and "By integrating with TTUHSC's EMR, Deep 6 AI's software platform can precision-match patients to trials".
- 17.Integrating AI-Enabled Clinical Trial Matching into Operations · Stillman R, Campbell A, Humphries K, Schweitzer C. The Ohio State University Comprehensive Cancer Center; AACI CRI 2024 abstract, 2024Customer work-in-progress abstract on Deep 6 AI at Ohio State, accessed September 2026. Quote: "a user interface that speeds patient screening by presenting and highlighting patient data related to the inclusion/exclusion criteria across a longitudinal patient record"; "to be able to reference the text in which the NLP identified the keywords to view the keywords in context to confirm the finding"; "Deep 6 AI can incorporate multiple data sources beyond the electronic medical records (EMR), such as genomics, custom databases, cancer registries, CTMS, etc."
- 18.Deep 6 AI homepage (archived) · Deep 6 AI, via the Internet Archive, 2026Internet Archive copy of January 3, 2026. Quotes: "Deep 6 AI has joined Tempus." and "Deep 6 AI is now a Tempus AI company". deep6.ai itself did not load when we checked on October 23, 2026.
- 19.Bond Health: platform overview, FAQ and pricing · Bond Health, 2026
- 20.Bond Health product information · Bond Health, 2026Capabilities, pricing and compliance status described by Bond Health, October 2026.
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