Enroll from the patients you already have

Where does enrollment break down at research sites?

Enrollment is uneven across the sites in a single trial. A 2013 Tufts CSDD analysis found that 11% of sites in a given trial typically enroll no patients and 37% under-enroll.^⁠[3]

• Staff time. In a 2012 study at one cancer center, the largest share of eligibility evaluations (35.8%) took 10 to 30 minutes, but more than 10% took 2 to 4 hours. Finding, screening and enrolling one patient took 3.4 to 8.8 research staff hours on average, by study type.^⁠[4]
• Staffing. In WCG's 2025 survey of 611 sites, 30% named site staffing a top challenge, and 28% named patient recruitment and retention (32% of smaller sites).^⁠[5]
• Turnover. In SCRS's 2022 survey, sites reported yearly turnover of patient-facing staff of 35% to 61%, against a typical 10% to 37%. SCRS puts the cost of recruiting and training a replacement at about six months' pay.^⁠[6]
• Screen failures. A patient who fails at the visit still costs the screening work. In a 2008 site-finance model, at a 10% screen-failure rate, nine enrolled patients must cover the screening cost of one failure.^⁠[7] See how to reduce screen failures.

Patient interest is often not the limit. In the 2020 national HINTS survey, only 9% of US adults had ever been invited to a clinical trial, but 47% of those invited took part.^⁠[8] The work is finding and asking the right patients.

How does Bond fit into a site's workflow?

Bond runs three stages as one workflow: identify, engage and consent. Decisions that need a coordinator or clinician stay with your team.^⁠[1]

1. 1

   Identify

   Bond reads structured and unstructured records against the study's inclusion and exclusion criteria, ranks candidates and shows the record evidence behind each criterion. It connects to all the major EHRs, including Epic, Oracle Health (Cerner), MEDITECH, athenahealth, eClinicalWorks, NextGen, Veradigm and OncoEMR. See Identify.^⁠[1],[2]

2. 2

   Engage

   Voice and SMS agents contact matched patients, say that AI assistance is being used, ask the questions in your approved pre-screening script, and book visits into your calendar. A patient can reach a person at any time: the agent transfers the call live to a coordinator or books a human callback, whichever the site prefers. See Engage.^⁠[1],[2]

3. 3

   Consent

   Bond gives patients plain-language explanations of the study, answers their questions and escalates to staff when needed. The PI or delegated staff still obtains consent. See Consent.^⁠[1]

4. 4

   Report

   A real-time dashboard and audit trail track each patient from match to randomization, and status can go to a Google Sheet or your CTMS.^⁠[1]

When a study needs more patients than your own records hold, Bond sets up Meta and Google ad campaigns for it.^⁠[2] Leads from those ads flow straight into the same voice and SMS agents for pre-screening and scheduling, alongside patients found in your EHR.^⁠[2]

After enrollment, the same voice and SMS agents send visit reminders, book transportation, collect symptoms and diaries, run side-effect check-ins and flag participants at risk of dropping out.^⁠[2]

Bond is a CRIO Certified Partner. It works alongside other CTMS and eRegulatory systems through API or file export where the vendor supports it. See all integrations.^⁠[1]

What changes day to day for coordinators and the PI?

• Coordinators check a ranked list and the evidence cited for each criterion instead of opening charts one at a time. They also handle escalations from the agents and run screening visits that are already booked.^⁠[1]
• The PI settles ambiguous criteria during setup, approves the outreach scripts, and obtains consent as before.
• Phone work narrows to the calls that need a person: live transfers, requested callbacks and questions outside the script.^⁠[2]
• Records of match rationale and outreach sit in one audit trail, which helps when a monitor asks why a patient was or was not approached.^⁠[1]

Which site problems does Bond address, and how is each measured?

Compare each measure with your own baseline: the same funnel on a similar study run the old way.

What results should the site expect to see reported?

Bond reports each study's funnel: patients matched, contacted, pre-screened, consented and randomized. Reports also show time to enrollment, matching accuracy, screen-failure signals and coordinator hours saved.^⁠[1]

These are Bond's published figures, not a forecast for your study. Results depend on the protocol, the population and how fast the site acts on matches. Funnel counts also help with sponsor feasibility requests; see how to win more studies and the feasibility questionnaire template.

Reduced our chart review time significantly while improving the quality of patients we bring in for screening.

What does implementation ask of the site?

A full deployment with the EHR connected takes 48 hours, depending on the EHR, the IT review and the interface method.^⁠[1] See the step-by-step implementation plan.

Site type changes the path. In WCG's 2025 survey, 54% of independent sites and physician practices said their study start-up took under 60 days, against 9% of academic medical centers, community hospitals, health systems and site networks.^⁠[5] A hospital-based site should bring in IT and security early. An independent site can start with a list-based pilot.

• Name a PI, a lead coordinator, an IT contact and a security contact.
• Sign a business associate agreement and run your vendor security review. Bond's controls are on the security page.
• Choose an interface: FHIR R4, HL7 v2 or an integration partner.
• Have the PI settle ambiguous criteria and a coordinator check a sample of Bond's matches against the chart.
• Edit the voice and text scripts and submit them to your IRB where required, using our IRB language template.
• Supply visit slots, escalation contacts and CTMS or sheet access.

How does pricing line up with site economics?

A site pays for screening on every patient, including those who fail, and recovers it from what it is paid for enrolled patients.^⁠[7] At one cancer center in 2012, manual screening cost $129 to $336 per enrolled patient, 6.5% to 16.7% of the average amount reimbursed per enrolled patient.^⁠[4]

Bond uses two-part pricing. A volume-based platform fee covers EHR integration, implementation and ongoing operation: the EHR connection, security review, audit logging, workflow configuration and ongoing support. There is no separate integration fee. A success fee is charged per enrolled patient, where "enrolled" means randomized, and per-visit milestones can be added.^⁠[1]

The variable part follows randomized patients, not referrals, calls or leads, so a patient who fails screening adds no success fee. Pricing is custom; see pricing.^⁠[1]